COVID-19-Associated Mucormycosis (CAM): An Updated Evidence Mapping

Investor logo
Investor logo

HUSSAIN Mohammad Salman BAXI Harveen RIAD Abanoub KLUGAROVÁ Jitka POKORNÁ Andrea SLEZÁKOVÁ Simona LÍČENÍK Radim NAJMI Abul Kalam KLUGAR Miloslav

Year of publication 2021
Type Article in Periodical
Magazine / Source Environmental Research and Public Health
MU Faculty or unit

Faculty of Medicine

Keywords COVID-19; diabetes; epidemiology; evidence; mortality; mucormycosis; mycoses; public health
Description Mucormycosis, a serious and rare fungal infection, has recently been reported in COVID-19 patients worldwide. This study aims to map all the emerging evidence on the COVID-19-associated mucormycosis (CAM) with a special focus on clinical presentation, treatment modalities, and patient outcomes. An extensive literature search was performed in MEDLINE (Ovid), Embase (Ovid), Cochrane COVID-19 Study Register, and WHO COVID-19 database till 9 June 2021. The primary outcome was to summarize the clinical presentation, treatment modalities, and patient outcomes of CAM. Data were summarized using descriptive statistics and presented in tabular form. This evidence mapping was based on a total of 167 CAM patients with a mean age of 51 ± 14.62 years, and 56.28% of them were male. Diabetes mellitus (73.65% (n = 123)), hypertension (22.75% (n = 38)), and renal failure (10.77% (n = 18)) were the most common co-morbidities among CAM patients. The most common symptoms observed in CAM patients were facial pain, ptosis, proptosis, visual acuity, and vision loss. Survival was higher in patients who underwent both medical and surgical management (64.96%). Overall mortality among CAM patients was found to be 38.32%. In conclusion, this study found a high incidence of CAM with a high mortality rate. Optimal glycemic control and early identification of mucormycosis should be the priority to reduce the morbidity and mortality related to CAM.
Related projects:

You are running an old browser version. We recommend updating your browser to its latest version.

More info