COVID-19-Associated Mucormycosis (CAM): An Updated Evidence Mapping

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HUSSAIN Mohammad Salman BAXI Harveen RIAD Abanoub KLUGAROVÁ Jitka POKORNÁ Andrea SLEZÁKOVÁ Simona LÍČENÍK Radim NAJMI Abul Kalam KLUGAR Miloslav

Rok publikování 2021
Druh Článek v odborném periodiku
Časopis / Zdroj Environmental Research and Public Health
Fakulta / Pracoviště MU

Lékařská fakulta

Citace
www https://www.mdpi.com/1660-4601/18/19/10340
Doi http://dx.doi.org/10.3390/ijerph181910340
Klíčová slova COVID-19; diabetes; epidemiology; evidence; mortality; mucormycosis; mycoses; public health
Popis Mucormycosis, a serious and rare fungal infection, has recently been reported in COVID-19 patients worldwide. This study aims to map all the emerging evidence on the COVID-19-associated mucormycosis (CAM) with a special focus on clinical presentation, treatment modalities, and patient outcomes. An extensive literature search was performed in MEDLINE (Ovid), Embase (Ovid), Cochrane COVID-19 Study Register, and WHO COVID-19 database till 9 June 2021. The primary outcome was to summarize the clinical presentation, treatment modalities, and patient outcomes of CAM. Data were summarized using descriptive statistics and presented in tabular form. This evidence mapping was based on a total of 167 CAM patients with a mean age of 51 ± 14.62 years, and 56.28% of them were male. Diabetes mellitus (73.65% (n = 123)), hypertension (22.75% (n = 38)), and renal failure (10.77% (n = 18)) were the most common co-morbidities among CAM patients. The most common symptoms observed in CAM patients were facial pain, ptosis, proptosis, visual acuity, and vision loss. Survival was higher in patients who underwent both medical and surgical management (64.96%). Overall mortality among CAM patients was found to be 38.32%. In conclusion, this study found a high incidence of CAM with a high mortality rate. Optimal glycemic control and early identification of mucormycosis should be the priority to reduce the morbidity and mortality related to CAM.
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