Slizniční pemfigoid s očním postižením
| Title in English | Mucous membrane pemphigoid with ocular involvement |
|---|---|
| Authors | |
| Year of publication | 2022 |
| Type | Conference abstract |
| MU Faculty or unit | |
| Citation | |
| Description | Mucous membrane pemphigoid is a rare autoimmune bullous disease with an annual incidence of 1 per million, typically starting at around 60 years of age. Clinical features include erosions with subsequent scarring, especially of the mucous membranes of the oral cavity, nose, eyes and genitals. Ocular pemphigoid is a severe type of mucous membrane pemphigoid affecting the conjunctiva. Due to the rarity of the disease, low sensitivity of standard investigations (histology and immunofluorescence investigation of tissue and serum) and unavailability of serological testing of laminin 332 and alpha6beta4 integrin (ELISA only for BP antigens), in many cases it is not possible to make an unequivocal diagnosis. We describe the case report of a fifty-two years old patient treatet for mucous membrane pemphigoid with ocular involvement dispensarized at 1st Department of Dermatovenerology St. Anne´s University Hospital Brno since 2020. The diagnosis was determined on the basis of clinical features and histological examination from concunctival epithelium. Dominant clinical features were fibrotisation of ocular conjunctiva and trihiasis. The patient was treated systemicaly with Prednisone and Dapsone and the disease activity is currently stable. |