Kardiovaskulární farmakoterapie u pacientek s triple negativním karcinomem prsu před a po léčbě antracykliny

Title in English Cardiovascular Pharmacotherapy in Patients with Triple Negative Breast Cancer Before and After Anthracycline Treatment


Year of publication 2023
Type Article in Periodical
Magazine / Source Klinická onkologie
MU Faculty or unit

Faculty of Medicine

Web https://www.linkos.cz/casopis-klinicka-onkologie/2023-10-28-supplementum-1/kardiovaskularni-farmakoterapie-u-pacientek-s-triple-negativnim-karcinomem-prsu/
Doi http://dx.doi.org/10.48095/ccko2023S123
Keywords cardiotoxicity; triple negative breast cancer; anthracyclines
Description Cardiovascular diseases represent the leading cause of death in developed countries. Cancer holds the second place in global statistics. Patients are often diagnosed with both these diseases, parallel pharmacological therapy of which brings about the probability of drug interactions. This may affect not only the anticancer treatment, but also the patient’s quality of life and prognosis. The paper presents retrospective analysis of data from 243 patients, with emphasis on the incidence of cardiovascular diseases and associated pharmacotherapy in patients diagnosed with triple negative breast cancer. All subjects were treated with neoadjuvant anthracycline chemotherapy at Masaryk Memorial Cancer Institute between 2015 and 2022. The cohort was characterized by following parameters: age, BMI, arterial blood pressure, left ventricular ejection fraction, ECG parameters including QTc assessment, diagnosed cardiovascular diseases, and regular medications taken before and shortly after anthracycline treatment. The analysis revealed that the most frequent cardiovascular disease was hypertension (45 patients before and 52 after chemotherapy). Before chemotherapy, the most frequently used antihypertensives were calcium channel blockers (19 patients), followed by ACE inhibitors (18 patients), ATII antagonists (17 patients), b-sympatholytic drugs (16 patients), and diuretics (12 patients). After completion of chemotherapy, b-sympatholytic drugs (24 patients) dominated in the treatment of hypertension, followed by calcium channel blockers (23 patients), ATII antagonists (19 patients), ACE inhibitors (17 patients), and diuretics (11 patients). Results of these retrospective study analyses were used to design a whole-body animal model focused on evaluation of the complex reactions of cardiovascular system to polytherapy of anthracyclines and antihypertensive drugs. The follow-up project will focus on the simultaneous effects of b-sympatholytic drugs and calcium channel blockers. The follow-up project mainly aims to evaluate the potential cardioprotective effect of antihypertensives during anthracycline therapy.
Related projects:

You are running an old browser version. We recommend updating your browser to its latest version.

More info