Resolving chromatin organization in chronic lymphocytic leukemia.

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Authors	ČERNOVSKÁ Karolína PORC Jakub Paweł ZÁVACKÁ Kristýna STRÁNSKÁ Kamila ADAMOVÁ Sabina ONDROUŠKOVÁ Eva JAROŠOVÁ Marie POSPÍŠILOVÁ Šárka PLEVOVÁ Karla
Year of publication	2023
Type	Conference abstract
MU Faculty or unit	Central European Institute of Technology
Citation
Attached files	CancerGenomics2023_EMBL_Abstract_Book_-_FINAL__1_.pdf
Description	The spatial chromatin organization has been recognized as essential for fundamental cell processes. Disruption of its hierarchical structure can be caused by chromosomal rearrangements, which, especially in cancer cells, lead to aberrant molecular signaling. We aim to study altered genome structure in chronic lymphocytic leukemia (CLL), the most common type of leukemia in adults. We are particularly interested in the analysis of long-distance chromatin interactions and the formation of topologically associated domains (TADs), which might play a role in CLL pathogenesis.
Related projects:	Advanced sequencing methods for deciphering structural variants in cancer genome National institute for cancer research Nové přístupy ve výzkumu, diagnostice a terapii hematologických malignit X