Pubertální růst dětí, které se narodily malé na svůj gestační věk (SGA), s malou výškou v dětství (SGA-SS). Výsledky léčby růstovým hormonem z dat české národní databáze REPAR

Title in English	Pubertal growth in children born small for gestational age (SGA) with persistent short stature (SGA-SS). Growth hormone treatment outcomes from data of the Czech countywide REPAR database
Authors	KODYTKOVÁ Aneta TONI Ledjona PLACHÝ Lukáš JÍROVÁ Barbora ALDHOON HAINEROVÁ Irena ALEKSIJEVIĆ Darina ČERNÁ Jana DVOŘÁKOVÁ Marcela EL-LABADIDI Eva KALVACHOVÁ Božena KOCOURKOVÁ Kamila KOTVALOVÁ Ivana MAGNOVÁ Olga NOVOTNÁ Dana OBERMANNOVÁ Barbora POMAHAČOVÁ Renata PRŮHOVÁ Štěpánka SOUČEK Ondřej STRNADEL Jiří ŠÍCHOVÁ Lucie ŠKVOR Jaroslav ŠNAJDEROVÁ Marta ŠUMNÍK Zdeněk ZAPLETALOVÁ Jiřina ŠILAR Jiří KOLOUŠKOVÁ Stanislava LEBL Jan
Year of publication	2023
Type	Article in Periodical
Magazine / Source	Česko-slovenská pediatrie
MU Faculty or unit	Faculty of Medicine
Citation
Web	https://www.prolekare.cz/casopisy/cesko-slovenska-pediatrie/2023-s3/pubertalni-rust-deti-ktere-se-narodily-male-na-svuj-gestacni-vek-sga-s-malou-vyskou-v-detstvi-sga-ss-vysledky-lecby-rustovym-hormonem-z-dat-ceske-narodni-databaze-repar-136399
Doi	http://dx.doi.org/10.55095/CSPediatrie2023/058
Keywords	small-for-gestational-age; SGA-SS; growth hormone; puberty; pubertal growth spurt; adult height
Description	Both pre-pubertal growth and magnitude of the pubertal growth spurt are the prerequisites of potential of growth hormone therapy to optimize final height. We analyzed impact of pre-pubertal and pubertal growth components on the total effect of growth hormone therapy in a cohort of 397 children (221 boys) registered in the Czech national database of growth hormone recipients REPAR. All were born small for gestational age, had persistent short stature in childhood (SGA-SS) and already achieved their near-final height. We separately evaluated children according to parental heights (with both parents over -2 ht-SDS, one below -2 ht-SDS, both below -2 ht-SDS) and according to their size at birth – low birth weight, low birth length, low both parameters. Up to treatment completion, treatment led to a height gain of 1,59 ht-SDS; of this, the pre-pubertal gain was 1,57 ht-SDS. Thus, ht-SDS remained unchanged within puberty, despite continuous growth hormone administration. The final ht-SDS gain adjusted for age 18 years was 0,91 (all three parameters p<0.0001 if compared to pre-treatment). Children with both parents taller than -2 SD and children with exclusively low birth weight had significantly better treatment outcomes. Analysis results of the REPAR database confirm efficacy of growth hormone therapy in SGA-SS children. The treatment success is based on pre-pubertal growth component. Therefore, a careful follow-up of children born SGA and a timely initiation of growth hormone therapy in early childhood are of crucial importance.