Decellularization of lung to yield three-dimensional scaffold for pulmonary tissue engineering
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| Year of publication | 2023 |
| Type | Conference abstract |
| Citation | |
| Description | The structural and physiological features of the lungs make the success of engineering an artificial lung model in vitro a challenge. From a slew of approaches utilized in pulmonary tissue engineering, this work focuses on the detergent-based decellularization method for obtaining a well-preserved human, pig, and mouse lung tissue scaffold. Decellularization is a method based on removing cells and the entire genetic material from a preexisting organ or tissue while preserving the composition, 3D microarchitecture, and biochemical and biophysical properties of the pulmonary tissue. These scaffolds may serve as in vitro near-to-native 3D pulmonary models, hydrogels, or bio-inks for 3D printing which hold a valuable opportunity for disease modeling, drug testing, and regeneration. |