Decellularization of lung to yield three-dimensional scaffold for pulmonary tissue engineering

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ČIMBOROVÁ Katarína PELKOVÁ Vendula KOTASOVÁ Hana SEDLÁKOVÁ Veronika HAMPL Aleš

Rok publikování 2023
Druh Konferenční abstrakty
Citace
Popis The structural and physiological features of the lungs make the success of engineering an artificial lung model in vitro a challenge. From a slew of approaches utilized in pulmonary tissue engineering, this work focuses on the detergent-based decellularization method for obtaining a well-preserved human, pig, and mouse lung tissue scaffold. Decellularization is a method based on removing cells and the entire genetic material from a preexisting organ or tissue while preserving the composition, 3D microarchitecture, and biochemical and biophysical properties of the pulmonary tissue. These scaffolds may serve as in vitro near-to-native 3D pulmonary models, hydrogels, or bio-inks for 3D printing which hold a valuable opportunity for disease modeling, drug testing, and regeneration.

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