Effects of sigma ligands BD737 and haloperidol on isolated rat hearts

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Authors	NOVÁKOVÁ Marie BRAVENÝ Pavel
Year of publication	2001
Type	Article in Periodical
Magazine / Source	Physiological Research
MU Faculty or unit	Faculty of Informatics
Citation
Field	Physiology
Keywords	sigma receptor; sigma ligand; cardiac contractility; cardiac arrhythmias
Description	Sigma receptors are known to modulate cardiac contractility in isolated cardiomyocytes. The effects of highly specific sigma receptor ligands BD737 and haloperidol were tested in isolated rat hearts. Previously described arrhythmogenic effects of sigma ligands in cardiac myocytes were confirmed in isolated rat hearts perfused according to Langendorff. The putative inotropic effect of the drugs remains controversial.