Effects of sigma ligands BD737 and haloperidol on isolated rat hearts

Varování

Publikace nespadá pod Lékařskou fakultu, ale pod Fakultu informatiky. Oficiální stránka publikace je na webu muni.cz.

Autoři	NOVÁKOVÁ Marie BRAVENÝ Pavel
Rok publikování	2001
Druh	Článek v odborném periodiku
Časopis / Zdroj	Physiological Research
Fakulta / Pracoviště MU	Fakulta informatiky
Citace
Obor	Fyziologie
Klíčová slova	sigma receptor; sigma ligand; cardiac contractility; cardiac arrhythmias
Popis	Sigma receptors are known to modulate cardiac contractility in isolated cardiomyocytes. The effects of highly specific sigma receptor ligands BD737 and haloperidol were tested in isolated rat hearts. Previously described arrhythmogenic effects of sigma ligands in cardiac myocytes were confirmed in isolated rat hearts perfused according to Langendorff. The putative inotropic effect of the drugs remains controversial.