Oxidativní stres a spinocelulární karcinom hlavy a krku
| Title in English | Oxidative stress in head and neck squamous cell carcinoma |
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| Authors | |
| Year of publication | 2006 |
| Type | Article in Proceedings |
| Conference | Sborník přednášek, 69. kongres České společnosti otorinolaryngologie a chirurgie hlavy a krku |
| MU Faculty or unit | |
| Citation | |
| Field | ORL, ophthalmology, stomatology |
| Keywords | oxidative stress;HNSCC |
| Description | Introdution: Much attention is paid to the role of reactive oxygen species in cancer over recent years. It is generally accepted that a cell under oxidative tress encounters increased risk of malignant transformation. The aim of the study was to investigate a role among (i) activity of the manganese superoxide dismutase (SOD); (ii) Ala-9Val polymorphism in the SOD gene and (iii) the progression of the head and neck squamous cell carcinoma (HNSCC). Materials and methods: Since July 2004 to June 2005, we measured parameters of oxidative stress in 67 patients with HNSCC who underwent tracheotomy during surgical treatment. 7 patients after tracheotomy for non-oncological indications were included in a control group. We estimated glutathion peroxidase (GPx) and superoxide dismutase (SOD)activity in erythrocytes and in alveolar macrophages in bronchoalveolar lavage fluid. Additionally we measured level of malondialdehyde (MDA) and tumor necrosis factor (TNF). Results: Our study revealed increased TNF, increased MDA, increased level of GPx in both, plasma and red blood cells, in patients with cancer. Conclusion: Elevation of oxidative stress parameters without compensatory elevation of level or activity of antioxidative enzymes entitles us to assume that oxidative stress plays an important role in cancerogenesis. |
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