The Effect of Head Injury Upon the Immune System
| Authors | |
|---|---|
| Year of publication | 2007 |
| Type | Article in Periodical |
| Magazine / Source | Bratislavské Lekárské Listy |
| MU Faculty or unit | |
| Citation | |
| Field | Neurology, neurosurgery, neurosciences |
| Keywords | severe head injuries; immune system; stress reaction; TH2 dominance |
| Description | Severe head injurier are characterized by high mortality and morbidity. In spite of guidelines based therapy the treatment is frequently unsuccessful. Extracranial infectious complications are considered to be an important problem during the course of recovery, and possibly immunological changes could explain their occurrence. Finally, TH2 dominance induces IgE levels accumulation. All these changes are strongly under effect of stress based release of endogenous glucocorticoids and catecholamine, which influence the complex network of cytokines and cell mediators. |
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