Immunohistochemical evidence for down-regulation of cannabinoid CB1 receptors in the rat mesencephalon after self-administration of methamphetamine
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| Year of publication | 2007 |
| Type | Appeared in Conference without Proceedings |
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| Description | Image analysis disclosed the higher intensity of immunostaining for CB1 receptors in selected mesencephalic structures of the control animals than in methamphetamine treated rats. The down-regulation of CB1 receptors can decrease an inhibiting influence of GABA and thus the dopaminergic pathway activation by methamphetamine might be more intensive. |
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