Polymorfismus v promotorové oblasti genu pro tumor nekrotizující faktor alfa u pacientů s revmatoidní artritidou
| Title in English | Polymorphism of the tumor necrosis factor promoter region in patients with rheumatoid arthritis |
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| Authors | |
| Year of publication | 2005 |
| Type | Article in Periodical |
| Magazine / Source | Česká revmatologie |
| MU Faculty or unit | |
| Citation | |
| Field | Other specializations of internal medicine |
| Keywords | Rheumatoid arthritis gene polymorphism TNF-alpha |
| Description | Rheumatoid arthritis (RA) is a model of multigenic disorder and genetic factors may be implicated in a susceptibility to disease initiation as well as a severity of disease course. Tumor necrosis factor alpha (TNF alpha) is a pleiotropic pro-inflammatory cytokine implicated in stimulation of T-cell immune response, up-regulation of proteolytic enzymes, prostaglandins, chemokines, over-expression of adhesion or HLA class II molecules. Elevated levels of TNF-alpha in plasma and synovial fluid from patients with rheumatoid arthritis may be associated with gene polymorphisms of TNF alpha and TNF beta. |