InGA LF Accelerate/SPARK

CALL 2024 - results

More information about Internal Grant Agency (InGA) at the website of the Grant Office

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  Get up to 500 000 CZK for the development of your research!

In order to evaluate the application potential of research and development results at FM MU and reach a significant shift in the process of their application in practice, the LF Accelerate project scheme was created within the Internal Grant Agency of the FM MU in the summer of 2021. The grant scheme is based on the principles of the successful SPARK Stanford Program.

The aim of the scheme is:

  • increasing the number and quality of the research and development results created at FM MU in order to apply them in practice,
  • increasing interactions between the FM MU and applied sphere, including increasing the awareness about research activities and results at FM MU,
  • support of applied research, experimental development, Proof of Concept and founding start-up/spin-off societies at FM MU. 

Necessities to implement the supported projects:

  • at least one result recognized according to the definition of types of results (RIV) achieved, or results of type O, kept as “other results”, dedicated mostly to the FM MU,
  • demonstrably established communication or cooperation with at least one commercial partner,
  • at least one application for follow-up funding submitted (external or internal schemes)
  • prepared marketing presentation of results, safe from the point of view of confidential information and published through suitable promotional channels.

The expert panel for assessing the application potential of individual support applications:

  • Mgr. Markéta Vlasáková, Ph.D., manager of intellectual property, Technology Transfer Office MU
  • MUDr. Jana Vinklerová, Ph.D., MBA, CZECRIN, head of CTC, access & development manager
  • Dr. Barbora Šumová, Senior Investment Associate at i&i Biotech Fund & Member of the Board of Directors
  • Dr. Scott Kraft, Faculty Lead - Innovation Hub at W21C, University of Calgary; Director of the SPARK Calgary program
  • prof. Craig Garner, Charité Berlin; previously Stanford University; Founder and Director of SPARK-BIH; Co-founder and Advisor, Navan Technologies, Inc. and  Balance Therapeutics, Inc.

DIRECTIVE ON INTERNAL GRANT AGENCY FM MU

Supported projects 2024
4TARGET: Novel eIF4F inhibitors for the treatment of drug-resistant melanoma

4TARGET: Novel eIF4F inhibitors for the treatment of drug-resistant melanoma

Principal investigator: Mgr. Stjepan Uldrijan, CSc., Department of Biology FM MU

Resistance of malignant melanoma to drugs targeting BRAF and MEK kinases is an important clinical problem. However, research results suggest that inhibitors of the eIF4F protein complex could suppress resistant cancer cells. Using a newly developed unique screening platform to identify eIF4F inhibitors, we successfully tested chemical libraries containing more than 85,000 low molecular weight compounds. We identified more than 200 candidate molecules potentially targeting eIF4F. In this project, the biological activity of the selected compounds will be validated in detail and further optimized in the "hit-to-lead" phase of new anticancer drug development.

Principal investigator: Mgr. Katarína Rebrošová, Department of Microbiology FM MU and SAUH

The aim of the project "Acoustic sorting device for non-contact presorting and sample enrichment before rapid identification and characterization of pathogens directly from human body fluids using a compact Raman spectroscopy-based device progenitors" is to develop an acoustic sorting device that increases the efficiency of a previously built compact device. This device, in conjunction with a Raman microspectrometer, is used to identify pathogens in human body fluids and at the same time to characterize their antimicrobial resistance. This would contribute to the early detection, treatment, and containment of antimicrobial resistance.   

Supported projects 2023

Principal Investigator: Mgr. Zuzana Sumbalová Koledová, Ph.D., Department of Histology and Embryology, FM MU

This project aims to further develop the unique biotechnology for milk production in the laboratory towards production of human breast milk. 

Principal investigator: MUDr. Jaromír Gumulec, Ph.D., Ústav patologické fyziologie LF MU

CELL-MECHANIQ: Cell deformability is potential important diagnostic predictor of tumor aggressiveness. The aim of this project is to test the practical aspects of quantitative phase imaging (QPI) in this context.

Principal Investigator: prof. RNDr. Monika Pávková Goldbergová, Ph.D., Department of Pathophysiology, FM MU

The aim of the project is development and characterisation of the advanced implants to significantly improve osseointegration and eliminate bacterial proliferation and biofilm production.

Supported projects 2022

Principal researcher: Mgr. Katarína Rebrošová, Department of Microbiology FM MU and SAUH

The project aims to prepare a compact device to detect and characterize microbes directly from human body fluids. Early identification of agents and their antimicrobial resistance profile can significantly improve the treatment of infection, reduce healthcare costs, alleviate the growing antimicrobial resistance and save lives.

Main researcher: doc. RNDR Petr Vaňhara, Ph.D., Department of Histology and Embryology FM MU

Stem cells and progenitors are an essential resource for the development of Advanced Therapy Medicinal Product (ATMP) drugs for advanced therapy and tissue engineering. The aim of the project is to translate new experimental quality control (QC) procedures into standard operational protocols.

Main researcher: Mgr. Stjepan Uldrijan, CSc., Department of Biology FM MU

High-throughput drug screening platforms are used to identify compounds with the desired biological activity that could lead to new therapies. The aim of the project is to develop a new cellular system for more efficient high-throughput screening of chemical libraries of compounds.

  Contact

Ing. Karolína Kašparová

Technology transfer manager, Office for Research and Quality


Phone: +420 549 49 3782
E‑mail:

Ing. Daniela Podzemná

Technology transfer assistant, Office for Research and Quality


E‑mail:

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