More information about Internal Grant Agency (InGA) at the website of the Grant Office
Get up to 500 000 CZK for the development of your research!
In order to evaluate the application potential of research and development results at FM MU and reach a significant shift in the process of their application in practice, the LF Accelerate project scheme was created within the Internal Grant Agency of the FM MU in the summer of 2021. The grant scheme is based on the principles of the successful SPARK Stanford Program.
The aim of the scheme is:
increasing the number and quality of the research and development results created at FM MU in order to apply them in practice,
increasing interactions between the FM MU and applied sphere, including increasing the awareness about research activities and results at FM MU,
support of applied research, experimental development, Proof of Concept and founding start-up/spin-off societies at FM MU.
Necessities to implement the supported projects:
at least one result recognized according to the definition of types of results (RIV) achieved, or results of type O, kept as “other results”, dedicated mostly to the FM MU,
demonstrably established communication or cooperation with at least one commercial partner,
at least one application for follow-up funding submitted (external or internal schemes)
prepared marketing presentation of results, safe from the point of view of confidential information and published through suitable promotional channels.
The expert panel for assessing the application potential of individual support applications:
4TARGET: Novel eIF4F inhibitors for the treatment of drug-resistant melanoma
Principal investigator: Mgr. Stjepan Uldrijan, CSc., Department of Biology FM MU
Resistance of malignant melanoma to drugs targeting BRAF and MEK kinases is an important clinical problem. However, research results suggest that inhibitors of the eIF4F protein complex could suppress resistant cancer cells. Using a newly developed unique screening platform to identify eIF4F inhibitors, we successfully tested chemical libraries containing more than 85,000 low molecular weight compounds. We identified more than 200 candidate molecules potentially targeting eIF4F. In this project, the biological activity of the selected compounds will be validated in detail and further optimized in the "hit-to-lead" phase of new anticancer drug development.
Principal investigator: Mgr. Katarína Rebrošová, Department of Microbiology FM MU and SAUH
The aim of the project "Acoustic sorting device for non-contact presorting and sample enrichment before rapid identification and characterization of pathogens directly from human body fluids using a compact Raman spectroscopy-based device progenitors" is to develop an acoustic sorting device that increases the efficiency of a previously built compact device. This device, in conjunction with a Raman microspectrometer, is used to identify pathogens in human body fluids and at the same time to characterize their antimicrobial resistance. This would contribute to the early detection, treatment, and containment of antimicrobial resistance.
Principal investigator: MUDr. Jaromír Gumulec, Ph.D., Ústav patologické fyziologie LF MU
CELL-MECHANIQ: Cell deformability is potential important diagnostic predictor of tumor aggressiveness. The aim of this project is to test the practical aspects of quantitative phase imaging (QPI) in this context.
Principal researcher: Mgr. Katarína Rebrošová, Department of Microbiology FM MU and SAUH
The project aims to prepare a compact device to detect and characterize microbes directly from human body fluids. Early identification of agents and their antimicrobial resistance profile can significantly improve the treatment of infection, reduce healthcare costs, alleviate the growing antimicrobial resistance and save lives.
Main researcher: doc. RNDR Petr Vaňhara, Ph.D., Department of Histology and Embryology FM MU
Stem cells and progenitors are an essential resource for the development of Advanced Therapy Medicinal Product (ATMP) drugs for advanced therapy and tissue engineering. The aim of the project is to translate new experimental quality control (QC) procedures into standard operational protocols.
Main researcher: Mgr. Stjepan Uldrijan, CSc., Department of Biology FM MU
High-throughput drug screening platforms are used to identify compounds with the desired biological activity that could lead to new therapies. The aim of the project is to develop a new cellular system for more efficient high-throughput screening of chemical libraries of compounds.
Ing. Karolína Kašparová
Technology transfer manager, Office for Research and Quality