Je nutno revakcinovat proti viru hepatitidy B při poklesu titru anti-HBs protilátek pod 10 IU/l?
| Title in English | Is it necessary to revaccinate against hepatitis B virus when the titer of anti-HBs drops below 10 IU/L? |
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| Authors | |
| Year of publication | 2016 |
| Type | Article in Periodical |
| Magazine / Source | Klinická mikrobiologie a infekční lékařství |
| MU Faculty or unit | |
| Citation | |
| Field | Epidemiology, infectious diseases and clinical immunology |
| Keywords | viral hepatitis B; revaccination; anti-HBs titer |
| Description | Viral hepatitis B still represents a major epidemiological issue worldwide. After recombinant vaccine administration, a titer of anti-HBs antibodies > 10 IU/L has long been considered to be seroprotective. Persons without this antibody level after complete vaccination are referred to as non-responders. A progressive decline in anti-HBs levels over years is also commonly seen in responders. Recently, there has been increasing evidence that the titer of anti-HBs > 10 IU/L does not provide 100% protection against infection and clini¬cally manifest illness. Additionally, an important role of cellular immune memory has been demonstrated - without any correlation with anti-HBs titer. Based on current knowledge, there is no need for regular anti-HBs titer testing or booster vaccination in immu-nocompetent individuals with anti-HBs < 10 IU/L. At present, regular serological testing and, if need be, revaccination to maintain anti-HBs > 10 IU/L are recommended in immunocompromised persons and after liver transplantation. |