Human iPSC-Derived Neural Models for Studying Alzheimer’s Disease: from Neural Stem Cells to Cerebral Organoids

Authors

BARÁK Martin FEDOROVÁ Veronika POSPÍŠILOVÁ Veronika RAŠKA Jan VOCHYÁNOVÁ Simona SEDMÍK Jiří HŘÍBKOVÁ Hana KLÍMOVÁ Hana VÁŇOVÁ Tereza BOHAČIAKOVÁ Dáša

Year of publication 2022
Type Article in Periodical
Magazine / Source Stem Cell Reviews and Reports
Citation
Web https://link.springer.com/article/10.1007/s12015-021-10254-3
Doi http://dx.doi.org/10.1007/s12015-021-10254-3
Keywords iPSCs; Neural differentiation; Alzheimer’s disease; In vitro differentiation; Neural stem cells; Neural progenitors; Neurons; Astrocytes; Microglia; Cerebral organoids
Description During the past two decades, induced pluripotent stem cells (iPSCs) have been widely used to study mechanisms of human neural development, disease modeling, and drug discovery in vitro. Especially in the field of Alzheimer’s disease (AD), where this treatment is lacking, tremendous effort has been put into the investigation of molecular mechanisms behind this disease using induced pluripotent stem cell-based models. Numerous of these studies have found either novel regulatory mechanisms that could be exploited to develop relevant drugs for AD treatment or have already tested small molecules on in vitro cultures, directly demonstrating their effect on amelioration of AD-associated pathology. This review thus summarizes currently used differentiation strategies of induced pluripotent stem cells towards neuronal and glial cell types and cerebral organoids and their utilization in modeling AD and potential drug discovery.

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