Chromatin conformation analysis reveals genome structural and functional complexity in chronic lymphocytic leukemia.

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Authors	ČERNOVSKÁ Karolína PORC Jakub Paweł ZÁVACKÁ Kristýna ONDROUŠKOVÁ Eva JAROŠOVÁ Marie POSPÍŠILOVÁ Šárka PLEVOVÁ Karla
Year of publication	2023
Type	Conference abstract
MU Faculty or unit	Central European Institute of Technology
Citation
Attached files	FEBS-Biochemistry_Congress_final_programme_abstract_book.pdf
Description	The spatial chromatin organization in the nucleus has been recognized to be essential for fundamental cell processes. Disruption of its hierarchical structure can be caused by chromosomal rearrangements, which, especially in cancer cells, lead to aberrant molecular signaling, affecting tumor phenotype. We aim to study altered genome structure in chronic lymphocytic leukemia (CLL), the most common type of leukemia of adults in the Western world. We are particularly interested in the complex karyotype (CK) that is known to be associated with poor clinical outcome. We assume that CK plays a key role in chromatin structure disruption, consequently affecting CLL behavior.
Related projects:	Advanced sequencing methods for deciphering structural variants in cancer genome National institute for cancer research Nové přístupy ve výzkumu, diagnostice a terapii hematologických malignit X