Targeted Therapies for AVMs: from the Bedside to the Bench and back

Dr. Ivan Radovanovic MD, PhD, ISFM/FMH (CH) is an Associate Professor in the Department of Surgery (Division of Neurosurgery) at the University of Toronto. He holds the Baxter and Alma Ricard Chair in Neurosurgery and is a staff neurosurgeon at University Health Network specializing in cerebrovascular and skull base neurosurgery. He is also a senior scientist at the Krembil Brain Institute where he leads a basic and translational research program dedicated to understanding the development of vascular anomalies such as vascular malformations and cerebral aneurysms. Dr. Radovanovic’s group has identified somatic activating mutations in KRAS and subsequent downstream MAPK (MEK) signaling activation in brain arteriovenous malformations elucidating the genetic origin of this disease