Dáša Bohačiaková Group

Bioinformatics in Stem Cell Neurobiology

Dr. Dasa Bohaciakova’s Neurobiology group studies Alzheimer’s disease (AD) pathogenesis in vitro using a large portfolio of neuronal stem cell-based systems, including 2D neurons and 3D cerebral organoids. We aim to study, and ultimately to understand, the mechanisms of AD initiation and potential treatment for AD. We collaborate with numerous Czech and International Laboratories, including Max Planck Institute, Germany; Aarhus University, Denmark; Amsterdam UMC, The Netherlands, and others. Our team currently consists of 5 Post-doctoral researchers, 2 Research Scientists, 2 Ph.D. students, and 2 undergrad students, who are all proficient in their fields of expertise.

We seek to complement our analytical tools with high-throughput bulk-mRNA/miRNA seq analyses as well as single-cell seq transcriptomics to fully exploit the potential of our unique model systems. As a part of the job, we offer participation in the relevant Bioinformatics training at EMBL-EBI or similar; 

Publications:

Barak, M., Fedorova, V., Pospisilova, V. et al. Human iPSC-Derived Neural Models for Studying Alzheimer’s Disease: from Neural Stem Cells to Cerebral Organoids. Stem Cell Rev and Rep 18, 792–820 (2022). https://doi.org/10.1007/s12015-021-10254-3

Michal Nemergut, Sergio Marques, Lukas Uhrik, Tereza Vanova, Marketa Nezvedova, Darshak Chandulal Gadara, Durga Jha, Jan Tulis, Veronika Blechova, Joan Iglesias-Planas, Antonin Kunka, Anthony Legrand, Hana Hribkova, Veronika Pospisilova, Jiri Sedmik, Jan Raska, Zbynek Prokop, Jiri Damborsky, Dasa Bohaciakova, Zdenek Spacil, Lenka Hernychova, David Bednar, Martin Marek.doi: https://doi.org/10.1101/2022.10.09.511473 

Marian Hruska-Plochan, Katharina M. Betz, Silvia Ronchi, Vera I. Wiersma, Zuzanna Maniecka, Eva-Maria Hock, Florent Laferriere, Sonu Sahadevan, Vanessa Hoop, Igor Delvendahl, Martina Panatta, Alexander van der Bourg, Dasa Bohaciakova, Karl Frontzek, Adriano Aguzzi, Tammaryn Lashley, Mark D. Robinson, Theofanis Karayannis, Martin Mueller, Andreas Hierlemann, Magdalini Polymenidou. doi: https://doi.org/10.1101/2021.12.08.471089

Mgr. Dáša Bohačiaková, Ph.D.

vedoucí výzkumné skupiny – Výzkumná skupina Dáši Bohačiakové: Neurobiology of the Development and Disease


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