Monika Pávková Goldbergová Group
The role of material modifications from the point of view of cytocompatibility
The work will be focused on studying the reaction of cells and/or tissues in the presence of metal materials commonly used for the production of joint replacements, including the study of metal debris, such as nanoparticles and metal ions. The fellows’ responsibility would include analyzing and interpreting data from multiple assays, including genomics, proteomics data, and data on toxicity. The candidate will develop research protocols, carry out experiments, collect, analyse, and interpret data, and have the responsibility to communicate progress and results clearly and effectively both within the laboratory and through presentations and publications.
The Laboratory of Materials in Medicine at the Faculty of Medicine, Masaryk University, led by Prof Monika Pavkova Goldbergova, provide a multi-disciplinary team that is focused on basic and applied research in the field of metals used in implantology and nanostructures (nanoparticles and nanostructured surfaces) and their effect on the organism, especially at the cellular and tissue levels. The overarching goal is the elucidation of the biological mechanisms driving healing and immune processes to improve metal incorporation.
VRCHOVECKÁ, Kateřina, Adam WEISER, Jan PŘIBYL, Jan KUTA, Jakub HOLZER, Monika PÁVKOVÁ GOLDBERGOVÁ, Dinara SOBOLA a Antonín DLOUHÝ. A release of Ti-ions from nanostructured titanium oxide surfaces. Surfaces and Interfaces. Amsterdam: Elsevier, 2022, 29, April 2022, 1-10. ISSN 2468-0230. doi:10.1016/j.surfin.2021.101699.
ŠTEFANČÍK, Michal, Lucie VÁLKOVÁ, Jana VEVERKOVÁ, Jan BALVAN, Tomáš VIČAR, Petr BABULA, Josef MASEK, Pavel KULICH a Monika PÁVKOVÁ GOLDBERGOVÁ. Ni and TiO2 nanoparticles cause adhesion and cytoskeletal changes in human osteoblasts. Environmental Science and Pollution Research. Heidelberg: Springer Heidelberg, 2021, 28:5, 6018-6029. ISSN 0944-1344. doi:10.1007/s11356-020-10908-8.
ŠEVČÍKOVÁ, Jana, Denisa BÁRTKOVÁ, Monika PÁVKOVÁ GOLDBERGOVÁ, Monika KUBĚNOVÁ, JIří ČERMÁK, Jan FRENZEL, Adam WEISER a Antonín DLOUHÝ. On the Ni-Ion release rate from surfaces of binary NiTi shape memory alloys. Applied Surface Science. Amsterdam: Elsevier Science BV., 2018, 427, 1 January 2018, 434-443. ISSN 0169-4332. doi:10.1016/j.apsusc.2017.08.235.