Nicola Silva Group
Chromosome Segregation During Gametogenesis
Faithful DNA repair and establishment of crossovers are essential for accurate segregation of the homologous chromosomes in the gametes and to preserve genome integrity across generations.
Nicola Silva’s team is interested in dissecting the pathways regulating these processes by studying several factors involved in the formation and repair of meiotic breaks, as well as by identifying novel proteins that promote recombination and licensing of chromosome synapsis, using Caenorhabditis elegans as model system.
Trivedi, S., Blazickova, J., Silva, N. (2022). PARG and BRCA1-BARD1 cooperative function regulates DNA repair pathway choice during gametogenesis. Nucleic Acids Research. DOI: 10.1093/nar/gkac1153.
Hicks, T., Trivedi, S., Eppert, M., Bowman, R., Tian, H., Dafalla, A., Crahan, C., Smolikove, S., Silva, N. (2022). Continuous double-strand break induction and their differential processing sustain chiasma formation during Caenorhabditis elegans meiosis. Cell Reports. DOI: 10.1016/j.celrep.2022.111403.
Janisiw, E., Raices, M., Balmir, F., Paulin, L.F., Baudrimont, A., von Haeseler, A., Yanowitz, J.L., Jantsch, V., Silva, N. (2020). Poly(ADP-ribose) glycohydrolase coordinates meiotic DNA double-strand break induction and repair independent of its catalytic activity. Nature Communications. DOI: 10.1038/s41467-020-18693-1