MDR1 in Paroxetine-Induced Sexual Dysfunction
| Autoři | |
|---|---|
| Rok publikování | 2013 |
| Druh | Článek v odborném periodiku |
| Časopis / Zdroj | Journal of Sex and Marital Therapy |
| Fakulta / Pracoviště MU | |
| Citace | |
| www | http://www.tandfonline.com/doi/pdf/10.1080/0092623X.2012.668514 |
| Doi | http://dx.doi.org/10.1080/0092623X.2012.668514 |
| Obor | Genetika a molekulární biologie |
| Klíčová slova | P-GLYCOPROTEIN; MDR1; Sexual Dysfunction |
| Popis | Paroxetine-induced sexual dysfunction represents a frequent treatment complication of otherwise efficient antidepressants. The genetic polymorphism of pharmacokinetic genes may contribute to the occurrence of such dysfunctions. This study presents the effect of MDR1 gene polymorphisms on sexual function in 18 women with bulimia nervosa, 18 women with anxiety disorders, and 19 healthy control subjects. It also deals with the relation between MDR1 gene polymorphisms and paroxetine-induced sexual dysfunction. The results demonstrated that MDR1 G2677T/A gene polymorphism allele carriers treated with paroxetine presented with difficulties with orgasm (p = .008) and lubrication (p < .001). |