DETERMINATION OF REFERENCE INTERVALS OF URINARY CYSTATIN C AND ITS RATIO TO URINARY CREATININE IN HEALTHY CHILDREN
| Název česky | STANOVENÍ REFERENČNÍCH INTERVALŮ CYSTATINU C V MOČI A JEHO POMĚRU KE KREATIININU V MOČI ZDRAVÝCH DĚTÍ |
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| Rok publikování | 2013 |
| Druh | Konferenční abstrakty |
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| Popis | The level of urinary cystatin C in urine in healthy adult individuals is 0.095 mg/l (0.033 – 0.29 mg/l) and it increases when increasing the age. Cystatin C is freely filtered in glomeruli and re-absorbed by the proximal tubular cells where it is also completely degraded. Increased urinary concentration of cystatin C is a marker of the functionality of cells. Disrupted glomerular filtration can be detected on the basis of increased levels of cystatin C in plasma. Plasma level of cystatin C increases with the age as a result of filtration rate decline. Aims of the study are to asses “normal“ cystatin C values in the urine of healthy children and to evaluate the obtained reference ranges after correction to urinary creatinine. |