MicroRNA-206: a Promising Theranostic Marker

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NOVÁK Jan KRUŽLIAK Peter BIENERTOVÁ VAŠKŮ Julie SLABÝ Ondřej NOVÁK Miroslav

Rok publikování 2014
Druh Článek v odborném periodiku
Časopis / Zdroj THERANOSTICS
Fakulta / Pracoviště MU

Lékařská fakulta

Citace
Doi http://dx.doi.org/10.7150/thno.7552
Obor Fyziologie
Klíčová slova microRNA-206; Theranostic Marker
Přiložené soubory
Popis MicroRNAs (miRs) are small non-coding RNAs that negatively regulate gene expression by binding to the 3 ' untranslated regions (3 ' UTR) of their target mRNAs. MiRs were shown to play pivotal roles in tissue development and function and are also involved in the pathogenesis of various diseases including cancer. MicroRNA-206, which belongs to the group of so-called "myomiRs", is one of the most studied miRs thus far. In addition to being involved in skeletal muscle development and pathology, it has also been established that it is involved in the pathogenesis of numerous diseases including heart failure, chronic obstructive pulmonary disease, Alzheimer's disease and various types of cancers. The aim of this review is to provide a complex overview of microRNA-206, including regulating its expression, a brief description of its known functions in skeletal muscle and a complex overview of its roles in the biology and pathology of other tissues, emphasizing its significant diagnostic and therapeutic potential.
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