CD36 and GPR120 differently mediate Ca2+ signaling in human taste bud cells

Varování

Publikace nespadá pod Lékařskou fakultu, ale pod Přírodovědeckou fakultu. Oficiální stránka publikace je na webu muni.cz.

Autoři	SUBRAMANIAM Selvakumar OZDENER Mehmet Hakan SUNDARESAN Sinju ŠERÝ Omar BESNARD Philippe ABUMRAD Nada A KHAN Naim Akhtar
Rok publikování	2014
Druh	Článek ve sborníku
Konference	FUNDAMENTAL & CLINICAL PHARMACOLOGY
Fakulta / Pracoviště MU	Přírodovědecká fakulta
Citace
Doi	http://dx.doi.org/10.1111/fcp.12064
Obor	Fyziologie
Klíčová slova	oral; fat; lipid; taste; bud
Popis	High concentrations of linoleic acid induced Ca(2+) signaling via CD36 and GPR120 in human and mice TBC, as well as in STC-1 cells, and low concentrations induced Ca(2+) signaling via only CD36. Incubation of human and mice fungiform TBC with lineoleic acid down-regulated CD36 and up-regulated GPR120 in membrane lipid rafts. Obese mice had decreased spontaneous preference for fat. Fungiform TBC from obese mice had reduced Ca(2+) and serotonin responses, but increased release of glucagon-like peptide-1, along with reduced levels of CD36 and increased levels of GPR120 in lipid rafts. CONCLUSIONS: CD36 and GPR120 have nonoverlapping roles in TBC signaling during orogustatory perception of dietary lipids; these are differentially regulated by obesity.
Související projekty:	Podpora biochemického výzkumu v roce 2016