Occupational exposure to endocrine disruptors and lymphoma risk in a multi-centric European study

Autoři	COSTAS L. INFANTE-RIVARD C. ZOCK J.P. VAN TONGEREN M. BOFFETTA P. CUSSON A. ROBLES C. CASABONNE D. BENAVENTE Y. BECKER N. BRENNAN P. FORETOVÁ Lenka MAYNADIE M. STAINES A. NIETERS A. COCCO P. SANJOSÉ S. de
Rok publikování	2015
Druh	Článek v odborném periodiku
Časopis / Zdroj	British journal of cancer
Fakulta / Pracoviště MU	Lékařská fakulta
Citace
Doi	http://dx.doi.org/10.1038/bjc.2015.83
Obor	Onkologie a hematologie
Klíčová slova	endocrine disruptors; chemicals; lymphoma; leukaemia; solvents; pesticides; alkylphenols
Popis	Background: Incidence rates of lymphoma are usually higher in men than in women, and oestrogens may protect against lymphoma. Methods: We evaluated occupational exposure to endocrine disrupting chemicals (EDCs) among 2457 controls and 2178 incident lymphoma cases and subtypes from the European Epilymph study. Results: Over 30 years of exposure to EDCs compared to no exposure was associated with a 24% increased risk of mature B-cell neoplasms (P-trend = 0.02). Associations were observed among men, but not women. Conclusions: Prolonged occupational exposure to endocrine disruptors seems to be moderately associated with some lymphoma subtypes.