A genome-wide association study of marginal zone lymphoma shows association to the HLA region
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VIJAI Joseph WANG Zhaoming BERNDT Sonja I. SKIBOLA Christine F. SLAGER Susan L. SANJOSE Silvia de MELBYE Mads GLIMELIUS Benght BRACCI Paige M. CONDE Lucia BIRMANN Brenda M. WANG Sophia S. BROOKS-WILSON Angela R. LAN Qing BAKKER Paul I.W. VERMEULEN Roel C.H. PORTLOCK Carol ANSELL Stephen M. LINK Brian K. RIBY Jacques NORTH Kari E. GU Jian HJALGRIM Henrik COZEN Wendy BECKER Nikolaus TERAS Lauren R. SPINELLI John J. TURNER Jenny ZHANG YaweiW PURDUE Mark P. GILES Graham G. KELLY Rachel S. ZELENIUCH-JACQUOTTE Anne ENNAS Maria Grazia MONNEREAU Alain BERTRAND Kimberly A. ALBANES Demetrius LIGHTFOOT Tracy YEAGER Meredith CHUNG Charles C. BURDETT Laurie HUTCHINSON Amy LAWRENCE Charles MONTALVAN Rebecca LIANG Liming HUANG Jinyan MA Baoshan VILLANO Danylo J. MARIA Ann CORINES Marina THOMAS Tinu NOVAK Anne J. DOGAN Ahmet LIEBOW Mark THOMPSON Carrie A. WITZIG Thomas E. HABERMANN Thomas M. WEINER George J. SMITH Martyn T. HOLLY Elizabeth JACKSON Rebecca D. TINKER Lesley F. YE Yuanging ADAMI Hans-Olov SMEDBY Karin E. DE ROOS Anneclaire HARTGE Patricia MORTON Lindsay M. SEVERSON Richard K. BENAVENTE Yolanda BOFFETTA Paolo BRENNAN Paul FORETOVÁ Lenka MAYNADIE Marc MCKAY James STAINES Anthony DIVER W. Ryan VAJDIC Claire M. ARMSTRONG Bruce K. KRICKER Anne ZHENG TongzhangZ HOLFORD Theodore R. SEVERI Gianluca VINEIS Paolo FERRI Giovanni M. RICCO Rosalia MILIGI Lucia CLAVEL Jacqueline GIOVANNUCCI Edward KRAFT Peter VIRTAMO Jarmo SMITH Alex KANE Eleanor ROMAN Eve CHIU Brian C.H. FRAUMENI Joseph F. WU Xifeng CERHAN James R. OFFIT Kenneth CHANOCK Stephen J. ROTHMAN Nathaniel NIETERS Alexandra |
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| Rok publikování | 2015 |
| Druh | Článek v odborném periodiku |
| Časopis / Zdroj | Nature Communications |
| Fakulta / Pracoviště MU | |
| Citace | |
| Doi | http://dx.doi.org/10.1038/ncomms6751 |
| Obor | Onkologie a hematologie |
| Klíčová slova | Marginal zone lymphoma; non-Hodgkin lymphoma |
| Popis | Marginal zone lymphoma (MZL) is the third most common subtype of B-cell non-Hodgkin lymphoma. Here we perform a two-stage GWAS of 1,281 MZL cases and 7,127 controls of European ancestry and identify two independent loci near BTNL2 (rs9461741, P - 3.95 x 10(-15)) and HLA-B (rs2922994, P - 2.43 x 10(-9)) in the HLA region significantly associated with MZL risk. This is the first evidence that genetic variation in the major histocompatibility complex influences MZL susceptibility. |