Prognosis of Good syndrome: mortality and morbidity of thymoma associated immunodeficiency in perspective

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JANSEN Anne DEUREN Marcel van MILLER Joanne LITZMAN Jiří GRACIA Javier de SÁENZ-CUESTA Matías SZAFLARSKA Anna MARTELIUS Timi TAKIGUCHI Yuichi PATEL Smita MISBAH Siraj SIMON Anna

Rok publikování 2016
Druh Článek v odborném periodiku
Časopis / Zdroj Clinical Immunology
Fakulta / Pracoviště MU

Lékařská fakulta

Citace
Doi http://dx.doi.org/10.1016/j.clim.2016.07.025
Obor Epidemiologie, infekční nemoci a klinická imunologie
Klíčová slova Immunodeficiency; Thymoma; Infection; Good syndrome
Popis Good syndrome (GS) or thymoma-associated immunodeficiency, is a rare condition that has only been studied in retrospective case series. General consensus was that GS has a worse prognosis than other humoral immunodeficiencies. In this study, physicians of GS patients completed two questionnaires with a two year interval with data on 47 patients, 499 patient years in total. Results on epidemiology, disease characteristics, and outcome are presented. Mean age at diagnosis was 60 years and median follow-up from onset of symptoms was 9 years. There was a high frequency of respiratory tract infections due to encapsulated bacteria. Median survival was 14 years. Survival was reduced compared to age-matched population controls (5-year survival: 82% versus 95%, p=0.008). In this cohort survival was not associated with gender (HR 0.9, 95% CI 0.3–3.0), autoimmune diseases (HR 2.9, 95% CI 0.8–10.1) or immunosuppressive use (HR 0.3, 95% CI: 0.1–1.2).

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