Buccal films as a dressing for the treatment of aphthous lesions



Rok publikování 2017
Druh Článek v odborném periodiku
Časopis / Zdroj Journal of Oral Pathology & Medicine
Fakulta / Pracoviště MU

Lékařská fakulta

Doi http://dx.doi.org/10.1111/jop.12563
Obor ORL, oftalmologie, stomatologie
Klíčová slova aphthous lesions; mucoadhesive buccal films; oral mucosa; pain reduction; residence time
Popis Background Buccal flexible films in the form of solid, thin, mucoadhesive patches can be used as dressings separating aphthous lesions from the environment of the oral cavity, which can in turn shorten the treatment period and reduce the pain perception. Methods The clinical study was performed on 36 volunteers suffering from aphthous lesions. The first group was treated using standard means—by application of an oral gel containing cholin salicylate (Mundisal) on the aphthous lesion. The second group was treated with the same preparation; however, the lesion was covered with a mucoadhesive film following the application of the gel. The criteria for statistical evaluation were the size of lesions in relation to the length of the treatment and the subjective perception of the treatment results. Results and conclusions The application of buccal films covering aphthous lesions during the treatment significantly increased the rate of healing when compared with the standard methods of treatment. While the pain improvement was statistically significant as soon as Day 3 in the experimental group, it was only apparent on Day 5 in the control group, and the number of successfully treated patients (pain perception improving to visual analogue scale 2 or less) was at all time points higher in the experimental group than in the control group. The results imply that the use of buccal films for treatment of aphthous lesions is very promising and can lead to a significant reduction in the duration of patients’ discomfort.

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