Genetic Contributions to The Association Between Adult Height and Head and Neck Cancer: A Mendelian Randomization Analysis

Autoři	PASTORINO Roberta PUGGINA Anna CARRERAS-TORRES Robert LAGIOU Pagona HOLCATOVA Ivana RICHIARDI Lorenzo KJAERHEIM Kristina AGUDO Antonio CASTELLSAGUE Xavier MACFARLANE Tatiana V. BARZAN Luigi CANOVA Cristina THAKKER Nalin S. CONWAY David I. ZNAOR Ariana HEALY Claire M. AHRENS Wolfgang ZARIDZE David SZESZENIA-DABROWSKA Neonilia LISSOWSKA Jolanta FABIANOVA Eleonora MATES Ioan Nicolae BENCKO Vladimír FORETOVÁ Lenka JANOUT Vladimir BRENNAN Paul GABORIEAU Valerie MCKAY James D. BOCCIA Stefania
Rok publikování	2018
Druh	Článek v odborném periodiku
Časopis / Zdroj	Scientific reports
Fakulta / Pracoviště MU	Lékařská fakulta
Citace
Doi	http://dx.doi.org/10.1038/s41598-018-22626-w
Klíčová slova	head and neck cancer
Popis	With the aim to dissect the effect of adult height on head and neck cancer (HNC), we use the Mendelian randomization (MR) approach to test the association between genetic instruments for height and the risk of HNC. 599 single nucleotide polymorphisms (SNPs) were identified as genetic instruments for height, accounting for 16% of the phenotypic variation. Genetic data concerning HNC cases and controls were obtained from a genome-wide association study. Summary statistics for genetic association were used in complementary MR approaches: the weighted genetic risk score (GRS) and the inverse-variance weighted (IVW). MR-Egger regression was used for sensitivity analysis and pleiotropy evaluation. From the GRS analysis, one standard deviation (SD) higher height (6.9 cm; due to genetic predisposition across 599 SNPs) raised the risk for HNC (Odds ratio (OR), 1.14; 95% Confidence Interval (95% CI), 0.99-1.32). The association analyses with potential confounders revealed that the GRS was associated with tobacco smoking (OR = 0.80, 95% CI (0.69-0.93)). MR-Egger regression did not provide evidence of overall directional pleiotropy. Our study indicates that height is potentially associated with HNC risk. However, the reported risk could be underestimated since, at the genetic level, height emerged to be inversely associated with smoking.