Could overexpression of an ONCOGENE represent a good prognostic factor in cancer?
|Popis||The c-Myb protein is a transcriptional regulator of stem cells maintenance in bone marrow, colon epithelia, and brain neurogenic niches. The pioneering research revealed that c-Myb is essential for normal hematopoiesis and identified it as important oncogene in various leukemias. The mechanism of its oncogenic function has been intensively studied in last decades and c-Myb is currently considered as a key regulator of balance between cell proliferation, differentiation and survival. Later studies found c-Myb overexpression in many carcinomas where its oncogenic function has been confirmed as well. Interestingly, we and others have recently shown that increased expression of c-Myb protein represents a good prognostic factor in breast and colon carcinomas. Our current research therefore aims to clarify this unusual phenomenon.|