A signature pattern of cortical atrophy in dementia with Lewy bodies: A study on 333 patients from the European DLB consortium

Varování

Publikace nespadá pod Lékařskou fakultu, ale pod Středoevropský technologický institut. Oficiální stránka publikace je na webu muni.cz.

Autoři	OPPEDAL Ketil FERREIRA Daniel CAVALLIN Lena LEMSTRA Afina W. TEN KATE Mara PADOVANI Alessandro REKTOROVÁ Irena BONANNI Laura WAHLUND Lars-Olof ENGEDAL Knut NOBILI Flavio KRAMBERGER Milica TAYLOR John-Paul HORT Jakub SNAEDAL Jon BLANC Frederic WALKER Zuzana ANTONINI Angelo WESTMAN Eric AARSLAND Dag
Rok publikování	2019
Druh	Článek v odborném periodiku
Časopis / Zdroj	ALZHEIMERS & DEMENTIA
Fakulta / Pracoviště MU	Středoevropský technologický institut
Citace
www	https://alz-journals.onlinelibrary.wiley.com/doi/abs/10.1016/j.jalz.2018.09.011
Doi	http://dx.doi.org/10.1016/j.jalz.2018.09.011
Klíčová slova	Dementia; Alzheimer's disease; Dementia with Lewy bodies
Popis	Introduction: We explored regional brain atrophy patterns and their clinical correlates in dementia with Lewy bodies (DLB). Methods: In this multicentre study, we included a total of 333 patients with DLB, 352 patients with Alzheimer's disease (AD), and 233 normal controls and used medial temporal lobe atrophy, posterior atrophy, and frontal atrophy (GCA-F) visual rating scales. Patients were classified according to four atrophy patterns. Results: Patients with DLB had higher scores on all the three atrophy scales than normal controls but had less medial temporal lobe atrophy than those with AD (all P values < 001). A signature hippocampal-sparing pattern of regional atrophy was observed in DLB. The magnetic resonance imaging measures showed 65% ability to discriminate between DLB and AD and marginally contributed to the discrimination over and above the core clinical features. Discussion: The most common pattern of atrophy of DLB was hippocampal-sparing. Future studies should explore whether comorbid AD pathology underlies the atrophy patterns seen in DLB. (C) 2018 Published by Elsevier Inc. on behalf of the Alzheimer's Association.