NMR Studies of Tau Protein in Tauopathies

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Publikace nespadá pod Lékařskou fakultu, ale pod Středoevropský technologický institut. Oficiální stránka publikace je na webu muni.cz.
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KITOKA K. SKRABANA R. GAŠPARIK Norbert HRITZ Jozef JAUDZEMS K.

Rok publikování 2021
Druh Článek v odborném periodiku
Časopis / Zdroj Frontiers in Molecular Biosciences
Fakulta / Pracoviště MU

Středoevropský technologický institut

Citace
www https://www.frontiersin.org/articles/10.3389/fmolb.2021.761227/full
Doi http://dx.doi.org/10.3389/fmolb.2021.761227
Klíčová slova tau; nuclear magnetic resonance; protein structure; Alzheimer's disease; filaments
Přiložené soubory
Popis Tauopathies, including Alzheimer's disease (AD), are the most troublesome of all age-related chronic conditions, as there are no well-established disease-modifying therapies for their prevention and treatment. Spatio-temporal distribution of tau protein pathology correlates with cognitive decline and severity of the disease, therefore, tau protein has become an appealing target for therapy. Current knowledge of the pathological effects and significance of specific species in the tau aggregation pathway is incomplete although more and more structural and mechanistic insights are being gained using biophysical techniques. Here, we review the application of NMR to structural studies of various tau forms that appear in its aggregation process, focusing on results obtained from solid-state NMR. Furthermore, we discuss implications from these studies and their prospective contribution to the development of new tauopathy therapies.
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