Soluble triggering receptor expressed on myeloid cells‑1 is a marker of organ injuries in cardiogenic shock: results from the CardShock Study

Autoři	KIMMOUN Antoine DUARTE Kevin HARJOLA Veli-Pekka TARVASMAKI Tuukka LEVY Bruno MEBAZAA Alexandre GIBOT Sebastien KONIARI Katerina VOUMVOURAKIS Astrinos KARAVIDAS Apostolos PARISSIS John SANS-ROSELLO Jordi VILA Montserrat DURAN-CAMBRA Albert SIONIS Alessandro PARENICA Jiri STIPAL Roman LUDKA Ondřej
Rok publikování	2022
Druh	Článek v odborném periodiku
Časopis / Zdroj	Clinical Research in Cardiology
Fakulta / Pracoviště MU	Lékařská fakulta
Citace
www	https://link.springer.com/content/pdf/10.1007/s00392-021-01823-0.pdf
Doi	http://dx.doi.org/10.1007/s00392-021-01823-0
Klíčová slova	Biomarkers; STREM; Cardiogenic Shock; Outcome
Popis	Optimal outcome after cardiogenic shock (CS) depends on a coordinated healing response in which both debris removal and extracellular matrix tissue repair play a crucial role. Excessive inflammation can perpetuate a vicious circle, positioning leucocytes as central protagonists and potential therapeutic targets. High levels of circulating Triggering Receptor Expressed on Myeloid cells-1 (TREM-1), were associated with death in acute myocardial infarction confirming excessive inflammation as determinant of bad outcome. The present study aims to describe the association of soluble TREM-1 with 90-day mortality and with various organ injuries in patients with CS.