Lupus-related single nucleotide polymorphisms and risk of diffuse large B-cell lymphoma

Autoři	BERNATSKY Sasha GARCI Hector A Velasque SPINELL John J GAFFNE Patric SMEDB Karin E RAMSEY-GOLDMA Rosalin WAN Sophia S ADAM Hans-Olo ALBANE Demetriu ANGELUCC Emanuel ANSEL Stephen M ASMAN Yan W BECKE Nikolau BENAVENT Yoland BERND Sonja I BERTRAN Kimberly A BIRMAN Brenda M BOEIN Heine BOFFETT Paol BRACC Paige M BRENNA Pau BROOKS-WILSO Angela R CERHA James R CHANOC Stephen J CLAVE Jacquelin COND Luci COTENBADE Karen H CO David G COZE Wend CROUC Simo DE Roo Anneclaire J DE Sanjos Silvi DI Loll Simonett DIVE W Rya DOGA Ahme FORETOVÁ Lenka GHESQUIERE Herv GILE Graham G GLIMELIU Beng HABERMAN Thomas M HAIOU Corinn HARTG Patrici HJALGRI Henri HOLFOR Theodore R HOLL Elizabeth A JACKSO Rebecca D KAAK Rudolp KAN Eleano KELL Rachel S KLEI Robert J KRAF Pete KRICKE Ann LA Qin CHARLE Lawrenc LIEBO Mar LIGHTFOO Trac LIN Brian K MAYNADI Mar MCKA Jame MELBY Mad MOLIN Thierry J MONNEREA Alai MORTO Lindsay M NIETER Alexandr NORT Kari E NOVA Anne J OFFI Kennet PURDU Mark P RAI Marc RIB Jacque ROMA Ev ROTHMA Nathanie SALLE Gille SEVER Gianluc SEVERSO Richard K SKIBOL Christine F SLAGE Susan L SMIT Ale SMIT Martyn T SOUTHE Melissa C STAINE Anthon TERA Lauren R THOMPSO Carrie A TILL Herv TINKE Lesley F TJONNELAN Ann TURNE Jenn VAJDI Claire M VERMEULE Roel C H VIJA Josep VINEI Paol VIRTAM Jarm WAN Zhaomin WEINSTEI Stephani WITZI Thomas E ZELENET Andre ZELENIUCH-JACQUOTT Ann ZHAN Yawe ZHEN Tongzhan ZUCC Mariagrazi CLARK Ann E
Rok publikování	2017
Druh	Článek v odborném periodiku
Časopis / Zdroj	LUPUS SCIENCE & MEDICINE
Fakulta / Pracoviště MU	Lékařská fakulta
Citace
www	https://lupus.bmj.com/content/4/1/e000187
Doi	http://dx.doi.org/10.1136/lupus-2016-000187
Klíčová slova	B-cell lymphoma; Lupus-related single nucleotide polymorphisms
Popis	Objective: Determinants of the increased risk of diffuse large B-cell lymphoma (DLBCL) in SLE are unclear. Using data from a recent lymphoma genome-wide association study (GWAS), we assessed whether certain lupus-related single nucleotide polymorphisms (SNPs) were also associated with DLBCL. Methods: GWAS data on European Caucasians from the International Lymphoma Epidemiology Consortium (InterLymph) provided a total of 3857 DLBCL cases and 7666 general-population controls. Data were pooled in a random-effects meta-analysis. Results: Among the 28 SLE-related SNPs investigated, the two most convincingly associated with risk of DLBCL included the CD40 SLE risk allele rs4810485 on chromosome 20q13 (OR per risk allele=1.09, 95% CI 1.02 to 1.16, p=0.0134), and the HLA SLE risk allele rs1270942 on chromosome 6p21.33 (OR per risk allele=1.17, 95% CI 1.01 to 1.36, p=0.0362). Of additional possible interest were rs2205960 and rs12537284. The rs2205960 SNP, related to a cytokine of the tumour necrosis factor superfamily TNFSF4, was associated with an OR per risk allele of 1.07, 95% CI 1.00 to 1.16, p=0.0549. The OR for the rs12537284 (chromosome 7q32, IRF5 gene) risk allele was 1.08, 95% CI 0.99 to 1.18, p=0.0765. Conclusions: These data suggest several plausible genetic links between DLBCL and SLE.