ASSOCIATION OF BARIATRIC SURGERY WITH THE RISK OF FRACTURE IN PATIENTS WITH OBESITY: A META-ANALYSIS OF REAL-WORLD EVIDENCE
| Autoři | |
|---|---|
| Rok publikování | 2022 |
| Druh | Konferenční abstrakty |
| Fakulta / Pracoviště MU | |
| Citace | |
| Popis | Background Evidence from published epidemiological studies found inconsistent evidence on the association of bariatric surgery with fracture risk. Objectives To evaluate the impact of bariatric surgery on fracture risk. Methods Electronic databases PubMed, and Embase were searched for studies assessing the association between bariatric surgery and fracture risk by two independent investigators. The study search period was from inception to September 2021. Study selection, data extraction, and risk of bias were assessed by investigators independently. Newcastle-Ottawa Scale (NOS) was used to assess the risk of bias. The primary outcome was to compute the pooled fracture risk in patients with obesity who underwent bariatric surgery. Secondary outcomes include fracture risk based on follow-up duration and sites of fracture (hip, upper limb). Certainty of findings was assessed using the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) criteria. Results This meta-analysis was based on seven studies with a total of 156233 patients with a mean age of 41.65 ± 10.63 years. Included studies were of low risk of bias. A significantly increased risk of any fracture was found in the bariatric surgery group as compared to the non-surgical group with a pooled relative risk (RR) of 1.34 (95% CI: 1.05 – 1.70), p= 0.02 |