JAK2V617F mutation and circulating extracellular vesicles in essential thrombocythemia

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ASWAD Mohamed Hussam KISSOVÁ Jarmila OVESNÁ Petra ŘÍHOVÁ Lucie PENKA Miroslav

Rok publikování 2023
Druh Článek v odborném periodiku
Časopis / Zdroj CLINICAL HEMORHEOLOGY AND MICROCIRCULATION
Fakulta / Pracoviště MU

Lékařská fakulta

Citace
www https://content.iospress.com/articles/clinical-hemorheology-and-microcirculation/ch221678
Doi http://dx.doi.org/10.3233/CH-221678
Klíčová slova Essential thrombocythemia; thrombosis; risk factor; JAK2V617F mutation; extracellular vesicles
Popis The clinical course of essential thrombocythemia (ET) is complicated with thrombosis which significantly impacts patients’ mortality. Studies have identified JAK2V617F mutation as an independent risk factor for thrombosis. Circulating extracellular vesicles (EVs) were evaluated in several studies regarding myeloproliferative neoplasms and thrombosis as potential biomarkers. The present study investigates the relationship between JAK2V617F mutation and EVs levels in 119 ET patients. Our analyses revealed that JAK2V617F-positive patients are at a significantly increased risk of thrombosis within five years before the ET diagnosis (hazard ratio [95% CI]: 11.9 [1.7–83.7], P?=?0.013), and that JAK2V617F mutation is an independent risk factor for thrombosis at ET diagnosis or during the follow-up (hazard ratio [95% CI]: 3.56 [1.47–8.62], P?=?0.005). ET patients have higher levels of platelet-EVs, erythrocyte-EVs and procoagulant activity of EVs than the healthy population. Absolute and relative counts of platelet-EVs are increased in the presence of JAK2V617F mutation (P?=?0.018, P?=?0.024, respectively). In conclusion, our results support the role of JAK2V617F mutation in the pathogenesis of thrombosis in essential thrombocythemia through enhancing platelet activation.

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