Olanzapine, but not haloperidol, exerts pronounced acute metabolic effects in the methylazoxymethanol rat model
| Název česky | Olanzapine, ale ne haloperidol, vyvolává akutní metabolické účinky v metylazoxymetanolovém potkaním modelu |
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| Autoři | |
| Rok publikování | 2024 |
| Druh | Článek v odborném periodiku |
| Časopis / Zdroj | CNS NEUROSCIENCE & THERAPEUTICS |
| Fakulta / Pracoviště MU | |
| Citace | |
| www | https://onlinelibrary.wiley.com/doi/10.1111/cns.14565 |
| Doi | http://dx.doi.org/10.1111/cns.14565 |
| Klíčová slova | adipokine; antipsychotic; lipid profile; methylazoxymethanol; schizophrenia |
| Popis | Our results demonstrate metabolic vulnerability in female prenatally MAM-exposed rats indicating that findings from healthy animals are likely to provide an underestimated impression of metabolic dysfunction associated with antipsychotics. In the context of metabolic disturbances, neurodevelopmental models possess a relevant background, and the search for adequate animal models should receive more attention within the field of experimental psychopharmacology. |
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