Behavioural effects of felbamate in the model of social interaction in mice
| Autoři | |
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| Rok publikování | 2002 |
| Druh | Článek v odborném periodiku |
| Časopis / Zdroj | Homeostasis |
| Fakulta / Pracoviště MU | |
| Citace | |
| Obor | Farmakologie a lékárnická chemie |
| Klíčová slova | animal behaviour; antidepressant; felbamate; mouse |
| Popis | Felbamate belongs to the antiepileptics of the third generation which are tested for their behavioural effects potentially useful particularly in depressive patients. The present study used the ethological model of agonistic behaviour based on the intra-species social conflict in male mice to investigate the effects of felbamate (15, 60 and 240 mg/kg, orally) on sociable, defensive-escape, aggressive and locomotor behaviour observed in singly-housed male mice during their social interactions with the non-aggressive group-housed male counterparts. In the aggressive mice felbamate produced a dose-dependent reduction in the behavioural score of aggressivity, significant after all doses tested. In the wide dosage interval of 15 - 240 mg/kg felbamate showed no sedative effect on locomotion, in addition, the ambulation was significantly disinhibited afte the dose of 15 mg/kg. The stimulatory effect of felbamate on locomotion was found also in the timid mice, significantly after the dose of 240 mg/kg, where at the same time an inhibition of defensive-escape behaviour occured, significantly after the lowest dose used (15 mg/kg). The tranquillising effect of felbamate on aggressive and timid mice behaviour described are similiar to those of the chemical analogue meprobamate found in the same model of mouse agonistic behaviour (Tomasikova and Krsiak, 1981), however, without sedation and with more marked antiaggressive effects in the aggressive group of mice isolates. |
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