Influence of ligands of serotonin receptors on the drug-metabolizing processes in the isolated perfused rat liver
| Název česky | Vliv ligando serotoninových receptoro na biotransformacní procesy |
|---|---|
| Autoři | |
| Rok publikování | 2002 |
| Druh | Článek v odborném periodiku |
| Časopis / Zdroj | Bratislavské lekárské listy |
| Fakulta / Pracoviště MU | |
| Citace | |
| Obor | Farmakologie a lékárnická chemie |
| Klíčová slova | izolated perfused liver; CYP2D1 |
| Popis | The effects of selective ligands of 5-HT3 and 5-HT1A/1B receptors, tropisetrone and RU 249, on N-acetylation and cytochrome P460-mediated metabolism in the isolated perfused rat liver were followed. The study has shown significant inhibition of acetylation, but a marked stimulation of CYP 2D1 activity after administration of both substances, with higher significance in RU 24969. |
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