Combined treatment with methamphetamine and fluoxetine influences pharmacokinetic behaviour of dextromethorphane in the rat
| Název česky | Vliv fluoxetinu na biotransformacní procesy metamfetaminu |
|---|---|
| Autoři | |
| Rok publikování | 2003 |
| Druh | Článek v odborném periodiku |
| Časopis / Zdroj | Psychiatrie |
| Fakulta / Pracoviště MU | |
| Citace | |
| Obor | Farmakologie a lékárnická chemie |
| Klíčová slova | methamphetamine; pharmacokinetics; dextromethorphan |
| Popis | The purpose of this study was to assess pharmacokinetics of dextromethorphane (model substrate of CYP2D2). The results suggest that fluoxetine therapy in methamphetamine dependece could slow down biodegradation of methamphetamine and this would enable to reduce methamphetamine doses without a decrease in psychotropic effect of drug. |
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