Influence of ligands of serotonin receptors on the drug-metabolizing processes in the isolated perfused rat liver.
| Název česky | Vliv ligandu serotoninových receptoru na metabolické procesy v systému izolovaných perfundovaných jater |
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| Autoři | |
| Rok publikování | 2003 |
| Druh | Článek ve sborníku |
| Konference | PROGRAMME AND ABSTRACTS of 5th NEUROCHEMISTRY WINTER CONFERENCE. |
| Fakulta / Pracoviště MU | |
| Citace | |
| Obor | Farmakologie a lékárnická chemie |
| Klíčová slova | isolated liver; CYP450 |
| Popis | The effects of selective ligands of 5-HT3 and 5-HT1A/1B receptors, tropisetrone and RU 249, on N-acetylation and cytochrome P460-mediated metabolism in the isolated perfused rat liver were followed. The study has shown significant inhibition of acetylation, but a marked stimulation of CYP 2D1 activity after administration of both substances, with higher significance in RU 24969. |
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