Survival and infertility treatment in male cancer patients after sperm banking
| Autoři | |
|---|---|
| Rok publikování | 2009 |
| Druh | Článek v odborném periodiku |
| Časopis / Zdroj | Fertility and Sterility |
| Fakulta / Pracoviště MU | |
| Citace | |
| Obor | Gynekologie a porodnictví |
| Klíčová slova | cryopreservation; semen; cancer survivors; male infertility |
| Popis | OBJECTIVE: The main aim of the study was to evaluate the relationship between sperm pathology and cancer diagnosis, determine the mortality rate, and evaluate the outcomes of the use of frozen sperm from the sperm bank. DESIGN: Prospective study. SETTING: University fertility center. PATIENT(S): A total of 619 male patients were referred for sperm freezing before gonadotoxic therapy from 1995 to 2006. INTERVENTION(S): Semen analysis, data verification in the National Oncological Register, assisted reproduction techniques, statistical evaluation. MAIN OUTCOME MEASURE(S): Cancer diagnosis and sperm pathology analysis, survival of patients and infertility treatment. RESULT(S): Malignant testicular cancer was diagnosed in 43.6% of patients, while malignant neoplasms of the lymphatic and haematopoietic tissues were found in 31.7% of patients. Azoospermia, or severe oligospermia were detected in 9.7% and 22.6% of patients, respectively. Until now, 32 patients (5.2%) have attended for infertility treatment. Cryopreserved semen was used in 28 couples (87.5%), 44 ICSI cycles resulted in 13 pregnancies. In total, 74 deaths (11.9%) were reported, 61 of them (82.4%) within 30 months of the cryopreservation of their sperm. CONCLUSION(S): Significant number of patients survived. Intrauterine insemination and ICSI with cryopreserved sperm resulted in deliveries. |
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