Role of thiamine status and genetic variability in transketolase and other pentose phosphate cycle enzymes in the progression of diabetic nephropathy
| Autoři | |
|---|---|
| Rok publikování | 2010 |
| Druh | Článek v odborném periodiku |
| Časopis / Zdroj | Nephrol Dial Transplant |
| Fakulta / Pracoviště MU | |
| Citace | |
| Obor | Ostatní obory vnitřního lékařství |
| Klíčová slova | diabetic nephropathy. pentose phosphate pathway. thiamine. thiamine deficiency. transketolase |
| Popis | Pentose phosphate pathway (PPP) represents a potentially protective mechanism in hyperglycaemia due to shunting of glycolytic intermediates into PPP reactions. We hypothesized that thiamine status (plasma and erythrocyte levels of thiamine and its esters) together with genetic variability in key PPP enzymes transketolase (TKT), transaldolase and TKT-like might contribute to the progression of diabetic nephropathy (DN) and mortality of diabetics. |