Genome-wide association study of follicular lymphoma identifies a risk locus at 6p21.32

• Autoři: CONDE L.; HALPERIN E.; AKERS N.; BROWN K.; SMEDBY K.; ROTHMAN N.; NIETERS A.; SLAGER S.; BROOKS-WILSON A.; AGANA L.; RIBY J.; LIU J.; ADAMI H.; DARABI H.; HJALGRIM H.; LOW H.; HUMPHREYS K.; MELBYE M.; CHANG E.; GLIMELIUS B.; COZEN W.; DAVIS S.; HARTGE P.; MORTON L.; SCHENK M.; WANG S.; ARMSTRONG B.; KRICKER A.; MILLIKEN S.; PURDUE M.; VAJDIC C.; BOYLE P.; LAN Q.; ZAHM S.; ZHANG Y.; ZHENG T.; BECKER N.; BENAVENTE Y.; BOFFETTA P.; BRENNAN P.; BUTTERBACH K.; COCCO P.; FORETOVÁ Lenka; MAYNADIE M.; DE SANJOSE S.; STAINES A.; SPINELLI J.; ACHENBACH S.; CALL T.; CAMP N.; GLENN M.; CAPORASO N.; CERHAN J.; CUNNINGHAM J.; GOLDIN L.; HANSON C.; KAY N.; LANASA M.; LEIS J.; MARTI G.; RABE K.; RASSENTI L.; SPECTOR L.; STROM S.; VACHON C.; WEINBERG J.; HOLLY E.; CHANOCK S.; SMITH M.; BRACCI P.; SKIBOLA Ch.
• Rok publikování: 2010
• Druh: Článek v odborném periodiku
• Časopis / Zdroj: Nature genetics
• Fakulta / Pracoviště MU: Lékařská fakulta
• Doi: http://dx.doi.org/10.1038/ng.626
• Obor: Genetika a molekulární biologie
• Klíčová slova: NON-HODGKIN-LYMPHOMA; NECROSIS-FACTOR TNF; HIGH-RESOLUTION; HLA; SUSCEPTIBILITY; HAPLOTYPE; POLYMORPHISMS
• Popis: To identify susceptibility loci for non-Hodgkin lymphoma subtypes, we conducted a three-stage genome-wide association study. We identified two variants associated with follicular lymphoma at 6p21.32 (rs10484561, combined P = 1.12 x 10(-29) and rs7755224, combined P = 2.00 x 10(-19); r(2) = 1.0), supporting the idea that major histocompatibility complex genetic variation influences follicular lymphoma susceptibility. We also found confirmatory evidence of a previously reported association between chronic lymphocytic leukemia/small lymphocytic lymphoma and rs735665 (combined P = 4.24 x 10(-9)).