Intravenous insulin therapy during lung resection does not affect lung function or surfactant proteins

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RUČKA Zdeněk KRONTORÁD KOUTNÁ Irena TESAŘOVÁ Lenka POTĚŠILOVÁ Michaela STEJSKAL Stanislav ŠIMARA Pavel VAŇHARA Petr DOLEŽEL Jan ZVONÍČEK Václav COUFAL Oldřich ČAPOV Ivan

Rok publikování 2014
Druh Článek v odborném periodiku
Časopis / Zdroj BMC Pulmonary Medicine
Fakulta / Pracoviště MU

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Citace
Doi http://dx.doi.org/10.1186/1471-2466-14-155
Obor Pneumologie
Klíčová slova surfactant proteins; insulin therapy
Popis The surgical resection of lung disrupts glucose homeostasis and causes hyperglycemia, as in any other major surgery or critical illness. We performed a prospective study where we carefully lowered hyperglycemia by insulin administration during the surgery, and for the first time we monitored immediate insulin effects on lung physiology and gene transcription.The levels of blood gases (pH, pCO2, pO2, HCO3-, HCO3- std, base excess, FiO2, and pO2/FiO2) were measured at the beginning of surgery, at the end of surgery, and two hours after. Samples of healthy lung tissue surrounding the tumour were obtained during the surgery, anonymized and sent for subsequent blinded qPCR analysis (mRNA levels of surfactant proteins A1, A2, B, C and D were measured). This study was done on a cohort of 64 patients who underwent lung resection. Patients were randomly divided, and half of them received insulin treatment during the surgery.We demonstrated for the first time that insulin administered intravenously during lung resection does not affect levels of blood gases. Furthermore, it does not induce immediate changes in the expression of surfactant proteins.According to our observations, short insulin treatment applied intravenously during resection does not affect the quality of breathing.
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