Can Bioactive Compounds of Crocus sativus L. Influence the Metabolic Activity of Selected CYP Enzymes in the Rat?
|Druh||Článek v odborném periodiku|
|Časopis / Zdroj||Physiological Research|
|Fakulta / Pracoviště MU|
|Obor||Farmakologie a lékárnická chemie|
|Klíčová slova||crocin; safranal; CYP; rat liver microsomes|
|Popis||The aim of the present study was to determine, whether systemic administration of safranal and crocin can influence the metabolic activity of CYP3A, CYP2C11, CYP2B, and CYP2A in rat liver microsomes (RLM). Our results demonstrate the ability of safranal and crocin to increase the total protein content and to change the metabolic activity of several CYP enzymes assessed as CYP specific hydroxylations of testosterone in RLM. Crocin significantly decreased the metabolic activity of all selected CYP enzymes, while safranal significantly increased the metabolic activity of CYP2B, CYP2C11 and CYP3A enzymes.|