Inherited ichthyoses: molecular causes of the disease in Czech patients

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Publikace nespadá pod Lékařskou fakultu, ale pod Přírodovědeckou fakultu. Oficiální stránka publikace je na webu muni.cz.

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BORSKÁ Romana PINKOVÁ Blanka RÉBLOVÁ Kamila BUČKOVÁ Hana KOPEČKOVÁ Lenka NĚMEČKOVÁ Jitka PUCHMAJEROVÁ Alena MALÍKOVÁ Marcela HERMANOVÁ Markéta FAJKUSOVÁ Lenka

Rok publikování 2019
Druh Článek v odborném periodiku
Časopis / Zdroj ORPHANET JOURNAL OF RARE DISEASES
Fakulta / Pracoviště MU

Přírodovědecká fakulta

Citace
www https://ojrd.biomedcentral.com/track/pdf/10.1186/s13023-019-1076-7
Doi http://dx.doi.org/10.1186/s13023-019-1076-7
Klíčová slova Autosomal recessive congenital ichthyosis; Keratinopathic ichthyosis; In silico analysis; 3D protein structure
Popis Inherited ichthyoses belong to a large and heterogeneous group of mendelian disorders of cornification, and can be distinguished by the quality and distribution of scaling and hyperkeratosis, by other dermatologic and extracutaneous involvement, and by inheritance. We present the genetic analysis results of probands with X-linked ichthyosis, autosomal recessive congenital ichthyosis, keratinopathic ichthyosis, and a patient with Netherton syndrome. Genetic diagnostics was complemented by in silico missense variant analysis based on 3D protein structures and commonly used prediction programs to compare the yields of these two approaches to each other. This analysis revealed various structural defects in proteins coded by mutated genes while no defects were associated with known polymorphisms. Two patients with pathogenic variants in the ABCA12 gene have a premature termination codon mutation on one allele and a silent variant on the second. The silent variants c.69G>A and c.4977G>A are localised in the last nucleotide of exon 1 and exon 32, respectively, and probably affect mRNA splicing. The phenotype of both patients is very severe, including a picture harlequin foetus after birth; later (at 3 and 6years of age, respectively) ectropin, eclabion, generalised large polygonal scaling and erythema.
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