Atomic Force Spectroscopy is a promising tool to study contractile properties of cardiac cells

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Publikace nespadá pod Lékařskou fakultu, ale pod Středoevropský technologický institut. Oficiální stránka publikace je na webu muni.cz.

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KABANOV Daniil KLIMOVIČ Šimon ROTREKL Vladimír PEŠL Martin PŘIBYL Jan

Rok publikování 2022
Druh Článek v odborném periodiku
Časopis / Zdroj Micron
Fakulta / Pracoviště MU

Středoevropský technologický institut

Citace
www https://doi.org/10.1016/j.micron.2021.103199
Doi http://dx.doi.org/10.1016/j.micron.2021.103199
Klíčová slova Atomic Force Microscopy; Force Spectroscopy; Biomechanics; Cardiomyocytes; Beat Rate; Contraction Force
Popis Atomic Force Microscopy (AFM) is a rather new method with increasing potential in analyzing various biosamples. Moreover, it can serve as a multi-functional device in the studies of biological specimens under physiological conditions. However, it is becoming increasingly popular among biochemists and biologists, it is not often used in cardiology. Heart disease causes millions of deaths every year. A common point in all heart diseases is the inferior function of cardiomyocytes, which are the contracting unit of the heart. Therefore, these cells are a frequent target of scientific studies. However, few of them use innovative techniques such as AFM and related methods or parallel combinations with complementary techniques such as cell potential measurements. The aim of this review is to illustrate the potential of AFM microscopy in the study of cardiac cells, comparing it with related methods and other techniques used to study the biomechanics and electrophysiology of this cell type. A better understanding of these methods may lead to a better description of the pathophysiology of the heart disease and an improved understanding of the effect of selected drugs.
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